MERIT, a cellular system coordinating lysosomal repair, removal and replacement.
Identifieur interne : 000092 ( Main/Exploration ); précédent : 000091; suivant : 000093MERIT, a cellular system coordinating lysosomal repair, removal and replacement.
Auteurs : Jingyue Jia [États-Unis] ; Aurore Claude-Taupin [États-Unis] ; Yuexi Gu [États-Unis] ; Seong Won Choi [États-Unis] ; Ryan Peters [États-Unis] ; Bhawana Bissa [États-Unis] ; Michal H. Mudd [États-Unis] ; Lee Allers [États-Unis] ; Sandeep Pallikkuth [États-Unis] ; Keith A. Lidke [États-Unis] ; Michelle Salemi [États-Unis] ; Brett Phinney [États-Unis] ; Muriel Mari [Pays-Bas] ; Fulvio Reggiori [Pays-Bas] ; Vojo Deretic [États-Unis]Source :
- Autophagy [ 1554-8635 ] ; 2020.
Abstract
Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a cellular system termed MERIT for lysosomal membrane repair, removal and replacement. Specifically, lysosomal membrane damage induces, in succession, ESCRT-dependent membrane repair, macroautophagy/autophagy-dominant removal of damaged lysosomes, and initiation of lysosomal biogenesis via transcriptional programs. The MERIT system is governed by galectins, a family of cytosolically synthesized lectins recognizing β-galactoside glycans. We found in this study that LGALS3 (galectin 3) detects membrane damage by detecting exposed lumenal glycosyl groups, recruits and organizes ESCRT components PDCD6IP/ALIX, CHMP4A, and CHMPB at damaged sites on the lysosomes, and facilitates ESCRT-driven repair of lysosomal membrane. At later stages, LGALS3 cooperates with TRIM16, an autophagy receptor-regulator, to engage autophagy machinery in removal of excessively damaged lysosomes. In the absence of LGALS3, repair and autophagy are less efficient, whereas TFEB nuclear translocation increases to compensate lysosomal deficiency via de novo lysosomal biogenesis. The MERIT system protects endomembrane integrity against a broad spectrum of agents damaging the endolysosomal network including lysosomotropic drugs, Mycobacterium tuberculosis, or neurotoxic MAPT/tau.
ABBREVIATIONS
AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for transport; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; TFEB: transcription factor EB; TFRC: transferrin receptor; TRIM16: tripartite motif-containing 16.
DOI: 10.1080/15548627.2020.1779451
PubMed: 32521192
PubMed Central: PMC7469593
Affiliations:
- Pays-Bas, États-Unis
- Californie, Groningue (province), Nouveau-Mexique
- Groningue
- Université de Groningue
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Jia</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Claude Taupin, Aurore" sort="Claude Taupin, Aurore" uniqKey="Claude Taupin A" first="Aurore" last="Claude-Taupin">Aurore Claude-Taupin</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Peters, Ryan" sort="Peters, Ryan" uniqKey="Peters R" first="Ryan" last="Peters">Ryan Peters</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Mudd, Michal H" sort="Mudd, Michal H" uniqKey="Mudd M" first="Michal H" last="Mudd">Michal H. Mudd</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Pallikkuth, Sandeep" sort="Pallikkuth, Sandeep" uniqKey="Pallikkuth S" first="Sandeep" last="Pallikkuth">Sandeep Pallikkuth</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Lidke, Keith A" sort="Lidke, Keith A" uniqKey="Lidke K" first="Keith A" last="Lidke">Keith A. Lidke</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Salemi, Michelle" sort="Salemi, Michelle" uniqKey="Salemi M" first="Michelle" last="Salemi">Michelle Salemi</name><affiliation wicri:level="2"><nlm:affiliation>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Phinney, Brett" sort="Phinney, Brett" uniqKey="Phinney B" first="Brett" last="Phinney">Brett Phinney</name><affiliation wicri:level="2"><nlm:affiliation>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mari, Muriel" sort="Mari, Muriel" uniqKey="Mari M" first="Muriel" last="Mari">Muriel Mari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Reggiori, Fulvio" sort="Reggiori, Fulvio" uniqKey="Reggiori F" first="Fulvio" last="Reggiori">Fulvio Reggiori</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><affiliation wicri:level="2"><nlm:affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="eISSN">1554-8635</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a cellular system termed MERIT for lysosomal <i>me</i>mbrane <i>re</i>pa<i>i</i>r, removal and replacemen<i>t</i>. Specifically, lysosomal membrane damage induces, in succession, ESCRT-dependent membrane repair, macroautophagy/autophagy-dominant removal of damaged lysosomes, and initiation of lysosomal biogenesis via transcriptional programs. The MERIT system is governed by galectins, a family of cytosolically synthesized lectins recognizing β-galactoside glycans. We found in this study that LGALS3 (galectin 3) detects membrane damage by detecting exposed lumenal glycosyl groups, recruits and organizes ESCRT components PDCD6IP/ALIX, CHMP4A, and CHMPB at damaged sites on the lysosomes, and facilitates ESCRT-driven repair of lysosomal membrane. At later stages, LGALS3 cooperates with TRIM16, an autophagy receptor-regulator, to engage autophagy machinery in removal of excessively damaged lysosomes. In the absence of LGALS3, repair and autophagy are less efficient, whereas TFEB nuclear translocation increases to compensate lysosomal deficiency via de novo lysosomal biogenesis. The MERIT system protects endomembrane integrity against a broad spectrum of agents damaging the endolysosomal network including lysosomotropic drugs, <i>Mycobacterium tuberculosis</i>, or neurotoxic MAPT/tau.</div><div type="abstract" xml:lang="en"><p><b>ABBREVIATIONS</b></p><p>AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for transport; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; TFEB: transcription factor EB; TFRC: transferrin receptor; TRIM16: tripartite motif-containing 16.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32521192</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>08</Month></PubDate></JournalIssue><Title>Autophagy</Title><ISOAbbreviation>Autophagy</ISOAbbreviation></Journal><ArticleTitle>MERIT, a cellular system coordinating lysosomal repair, removal and replacement.</ArticleTitle><Pagination><MedlinePgn>1539-1541</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2020.1779451</ELocationID><Abstract><AbstractText>Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a cellular system termed MERIT for lysosomal <i>me</i>mbrane <i>re</i>pa<i>i</i>r, removal and replacemen<i>t</i>. Specifically, lysosomal membrane damage induces, in succession, ESCRT-dependent membrane repair, macroautophagy/autophagy-dominant removal of damaged lysosomes, and initiation of lysosomal biogenesis via transcriptional programs. The MERIT system is governed by galectins, a family of cytosolically synthesized lectins recognizing β-galactoside glycans. We found in this study that LGALS3 (galectin 3) detects membrane damage by detecting exposed lumenal glycosyl groups, recruits and organizes ESCRT components PDCD6IP/ALIX, CHMP4A, and CHMPB at damaged sites on the lysosomes, and facilitates ESCRT-driven repair of lysosomal membrane. At later stages, LGALS3 cooperates with TRIM16, an autophagy receptor-regulator, to engage autophagy machinery in removal of excessively damaged lysosomes. In the absence of LGALS3, repair and autophagy are less efficient, whereas TFEB nuclear translocation increases to compensate lysosomal deficiency via de novo lysosomal biogenesis. The MERIT system protects endomembrane integrity against a broad spectrum of agents damaging the endolysosomal network including lysosomotropic drugs, <i>Mycobacterium tuberculosis</i>, or neurotoxic MAPT/tau.</AbstractText><AbstractText Label="ABBREVIATIONS">AMPK: AMP-activated protein kinase; APEX2: engineered ascorbate peroxidase 2; ATG13: autophagy related 13; ATG16L1: autophagy related 16 like 1; BMMs: bone marrow-derived macrophages; ESCRT: endosomal sorting complexes required for transport; GPN: glycyl-L-phenylalanine 2-naphthylamide; LLOMe: L-leucyl-L-leucine methyl ester; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MERIT: membrane repair, removal and replacement; MTOR: mechanistic target of rapamycin kinase; TFEB: transcription factor EB; TFRC: transferrin receptor; TRIM16: tripartite motif-containing 16.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Jingyue</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Claude-Taupin</LastName><ForeName>Aurore</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Yuexi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Seong Won</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bissa</LastName><ForeName>Bhawana</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mudd</LastName><ForeName>Michal H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allers</LastName><ForeName>Lee</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pallikkuth</LastName><ForeName>Sandeep</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lidke</LastName><ForeName>Keith A</ForeName><Initials>KA</Initials><Identifier Source="ORCID">0000-0002-9328-4318</Identifier><AffiliationInfo><Affiliation>Department of Physics and Astronomy, University of New Mexico , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salemi</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phinney</LastName><ForeName>Brett</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Proteomics Core Facility, UC Davis Genome Center, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mari</LastName><ForeName>Muriel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reggiori</LastName><ForeName>Fulvio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences & Systems, University of Groningen, University Medical Center Groningen , Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deretic</LastName><ForeName>Vojo</ForeName><Initials>V</Initials><Identifier Source="ORCID">0000-0002-3624-5208</Identifier><AffiliationInfo><Affiliation>Autophagy, Inflammation and Metabolism Center of Biochemical Research Excellence, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center , Albuquerque, NM, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P20 GM121176</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI111935</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AI042999</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10 OD021801</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Autophagy</MedlineTA><NlmUniqueID>101265188</NlmUniqueID><ISSNLinking>1554-8627</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Autophagy</Keyword><Keyword MajorTopicYN="Y">ESCRT</Keyword><Keyword MajorTopicYN="Y">TFEB</Keyword><Keyword MajorTopicYN="Y">TRIM</Keyword><Keyword MajorTopicYN="Y">tauopathies</Keyword><Keyword MajorTopicYN="Y">transferrin receptor</Keyword><Keyword MajorTopicYN="Y">tuberculosis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>06</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32521192</ArticleId><ArticleId IdType="doi">10.1080/15548627.2020.1779451</ArticleId><ArticleId IdType="pmc">PMC7469593</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Dev Cell. 2020 Jan 6;52(1):69-87.e8</Citation><ArticleIdList><ArticleId IdType="pubmed">31813797</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Californie</li><li>Groningue (province)</li><li>Nouveau-Mexique</li></region><settlement><li>Groningue</li></settlement><orgName><li>Université de Groningue</li></orgName></list><tree><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Jia, Jingyue" sort="Jia, Jingyue" uniqKey="Jia J" first="Jingyue" last="Jia">Jingyue Jia</name></region><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><name sortKey="Allers, Lee" sort="Allers, Lee" uniqKey="Allers L" first="Lee" last="Allers">Lee Allers</name><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><name sortKey="Choi, Seong Won" sort="Choi, Seong Won" uniqKey="Choi S" first="Seong Won" last="Choi">Seong Won Choi</name><name sortKey="Claude Taupin, Aurore" sort="Claude Taupin, Aurore" uniqKey="Claude Taupin A" first="Aurore" last="Claude-Taupin">Aurore Claude-Taupin</name><name sortKey="Claude Taupin, Aurore" sort="Claude Taupin, Aurore" uniqKey="Claude Taupin A" first="Aurore" last="Claude-Taupin">Aurore Claude-Taupin</name><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><name sortKey="Gu, Yuexi" sort="Gu, Yuexi" uniqKey="Gu Y" first="Yuexi" last="Gu">Yuexi Gu</name><name sortKey="Jia, Jingyue" sort="Jia, Jingyue" uniqKey="Jia J" first="Jingyue" last="Jia">Jingyue Jia</name><name sortKey="Lidke, Keith A" sort="Lidke, Keith A" uniqKey="Lidke K" first="Keith A" last="Lidke">Keith A. Lidke</name><name sortKey="Mudd, Michal H" sort="Mudd, Michal H" uniqKey="Mudd M" first="Michal H" last="Mudd">Michal H. Mudd</name><name sortKey="Mudd, Michal H" sort="Mudd, Michal H" uniqKey="Mudd M" first="Michal H" last="Mudd">Michal H. Mudd</name><name sortKey="Pallikkuth, Sandeep" sort="Pallikkuth, Sandeep" uniqKey="Pallikkuth S" first="Sandeep" last="Pallikkuth">Sandeep Pallikkuth</name><name sortKey="Peters, Ryan" sort="Peters, Ryan" uniqKey="Peters R" first="Ryan" last="Peters">Ryan Peters</name><name sortKey="Peters, Ryan" sort="Peters, Ryan" uniqKey="Peters R" first="Ryan" last="Peters">Ryan Peters</name><name sortKey="Phinney, Brett" sort="Phinney, Brett" uniqKey="Phinney B" first="Brett" last="Phinney">Brett Phinney</name><name sortKey="Salemi, Michelle" sort="Salemi, Michelle" uniqKey="Salemi M" first="Michelle" last="Salemi">Michelle Salemi</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Mari, Muriel" sort="Mari, Muriel" uniqKey="Mari M" first="Muriel" last="Mari">Muriel Mari</name></region><name sortKey="Reggiori, Fulvio" sort="Reggiori, Fulvio" uniqKey="Reggiori F" first="Fulvio" last="Reggiori">Fulvio Reggiori</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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